Analyses and Correlation of Pathologic and Ocular Cutaneous Changes in Murine Graft versus Host Disease

International Journal of Molecular Sciences

Robert B. Levy¹  Henry Barreras¹  Stephanie Duffort¹  Casey O. Lightbourn¹  Ryan Flynn²  Katelyn Paz²  Bruce R. Blazar²  Jing Du²  Michael Zaiken²  Victor L. Perez³  David Latoni³  Eric J. Shiuey³  Hazem M. Mousa³ 

[1] Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA;Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA;School of Medicine, Duke University, Durham, NC 27708, USA;

关键词: ocular GVHD;    cutaneous GVHD;    correlation;    pathology;    ocular immune response;    inflammation;   

DOI  :  10.3390/ijms23010184

来源: DOAJ

【 摘 要 】

Graft versus host disease (GVHD) is initiated by donor allo-reactive T cells activated against recipient antigens. Chronic GVHD (cGVHD) is characterized by immune responses that may resemble autoimmune features present in the scleroderma and Sjogren’s syndrome. Unfortunately, ocular involvement occurs in approximately 60–90% of patients with cGVHD following allo-hematopoietic stem cell transplants (aHSCT). Ocular GVHD (oGVHD) may affect vision due to ocular adnexa damage leading to dry eye and keratopathy. Several other compartments including the skin are major targets of GVHD effector pathways. Using mouse aHSCT models, the objective was to characterize cGVHD associated alterations in the eye and skin to assess for correlations between these two organs. The examination of multiple models of MHC-matched and MHC-mismatched aHSCT identified a correlation between ocular and cutaneous involvement accompanying cGVHD. Studies detected a “positive” correlation, i.e., when cGVHD-induced ocular alterations were observed, cutaneous compartment alterations were also observed. When no or minimal ocular signs were detected, no or minimal skin changes were observed. In total, these findings suggest underlying cGVHD-inducing pathological immune mechanisms may be shared between the eye and skin. Based on the present observations, we posit that when skin involvement is present in aHSCT patients with cGVHD, the evaluation of the ocular surface by an ophthalmologist could potentially be of value.

【 授权许可】

Unknown