The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

Molecular Cancer

Yosef Yarden¹  Xueping Wang²  Mengjun Zhong²  Fang Wang²  Liwu Fu² 

[1] Department of Biological Regulation, Weizmann Institute of Science;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center;

关键词: Immunotherapy;    PD-1/PD-L1;    Hyperprogressive disease;    Biomarker;   

DOI  :  10.1186/s12943-020-01200-x

来源: DOAJ

【 摘 要 】

Abstract Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers. However, low response rates to ICI monotherapies and even hyperprogressive disease (HPD) have limited the clinical application of ICIs. HPD is a novel pattern of progression, with an unexpected and fast progression in tumor volume and rate, poor survival of patients and early fatality. Considering the limitations of ICI due to HPD incidence, valid biomarkers are urgently needed to predict the occurrence of HPD and the efficacy of ICI. Here, we reviewed and summarized the known biomarkers of HPD, including tumor cell biomarkers, tumor microenvironment biomarkers, laboratory biomarkers and clinical indicators, which provide a potential effective approach for selecting patients sensitive to ICI cancer treatments.

【 授权许可】

Unknown