Cognitive Performance at Time of AD Diagnosis: A Clinically Augmented Register-Based Study

Frontiers in Psychology

Johanna Krüger¹  Noora-Maria Suhonen²  Tiia Ngandu³  Miia Kivipelto⁵  Sanna Koskinen⁷  Laura Hokkanen⁷  Mira Karrasch⁸  Marja-Liisa Laakkonen⁹  Tuomo Hänninen^1,10  Minna Alenius^1,11  Ilona Hallikainen^1,13  Minna M. Raivio^1,14 

[1] 0MRC, Oulu University Hospital, Oulu, Finland;1Department of Neurology, Oulu University Hospital, Oulu, Finland;2Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden;3Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;4Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom;Department of General Practice, University of Helsinki, Helsinki, Finland;Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland;Department of Psychology, Abo Akademi University, Turku, Finland;Geriatric Clinic, Department of Social Services and Health Care, Laakso Hospital, Helsinki, Finland;Neurology of Neuro Center, Kuopio University Hospital, Kuopio, Finland;Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland;Research Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland;Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland;Unit of Primary Health Care, Helsinki University Hospital, Helsinki, Finland;

关键词: cognitive screening;    cognitive performance;    Alzheimer’s disease;    CERAD;    timely diagnosis;    mixed dementia;   

DOI  :  10.3389/fpsyg.2022.901945

来源: DOAJ

【 摘 要 】

We aimed to evaluate the feasibility of using real-world register data for identifying persons with mild Alzheimer’s disease (AD) and to describe their cognitive performance at the time of diagnosis. Patients diagnosed with AD during 2010–2013 (aged 60–81 years) were identified from the Finnish national health registers and enlarged with a smaller private sector sample (total n = 1,268). Patients with other disorders impacting cognition were excluded. Detailed clinical and cognitive screening data (the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery [CERAD-nb]) were obtained from local health records. Adequate cognitive data were available for 389 patients with mild AD (31%) of the entire AD group. The main reasons for not including patients in analyses of cognitive performance were AD diagnosis at a moderate/severe stage (n = 266, 21%), AD diagnosis given before full register coverage (n = 152, 12%), and missing CERAD-nb data (n = 139, 11%). The cognitive performance of persons with late-onset AD (n = 284), mixed cerebrovascular disease and AD (n = 51), and other AD subtypes (n = 54) was compared with that of a non-demented sample (n = 1980) from the general population. Compared with the other AD groups, patients with late-onset AD performed the worst in word list recognition, while patients with mixed cerebrovascular disease and AD performed the worst in constructional praxis and clock drawing tests. A combination of national registers and local health records can be used to collect data relevant for cognitive screening; today, the process is laborious, but it could be improved in the future with refined search algorithms and electronic data.

【 授权许可】

Unknown