Anxiety and 10-Year Risk of Incident Dementia—An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study

Frontiers in Neuroscience

Tasnime N. Akbaraly¹  Meriem Abdennour³  Marion Mortamais³  Claudine Berr³  Audrey Gabelle⁵  Christophe Tzourio⁶  Valérie Bergua⁶ 

[1] Autism Resources Centre of Languedoc-Roussillon, University Hospital of Montpellier, CHRU de Montpellier, Montpellier, France;Department of Epidemiology and Public Health, University College London, London, United Kingdom;Institut National de la Santé et de la Recherche Médicale, Université de Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France;MMDN, Université de Montpellier, EPHE, Institut National de la Santé et de la Recherche Médicale, U1198, Montpellier, France;Memory Resources and Research Center, Department of Neurology, Gui de Chauliac Hospital, Montpellier, France;University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, Bordeaux, France;

关键词: anxiety;    Spielberger State-Trait Anxiety Inventory;    depressive symptoms;    aging;    dementia;    risk factors;   

DOI  :  10.3389/fnins.2018.00248

来源: DOAJ

【 摘 要 】

Background: Anxiety is common in patients with cognitive impairment and dementia. However, whether anxiety is a risk factor for dementia is still not known. We aimed to examine the association between trait anxiety at baseline and the 10-year risk of incident dementia to determine to which extent depressive symptoms influence this relationship in the general population.Methods: Data came from 5,234 community-dwelling participants from the Three-City prospective cohort study, aged 65 years at baseline and followed over 10 years. At baseline, anxiety trait was assessed using the Spielberger State-Trait Anxiety Inventory (STAI), and depressive symptoms using Center for Epidemiologic Studies-Depression Scale (CESD). Use of anxiolytic drugs was also considered. Diagnoses of dementia were made at baseline and every 2 years. To examine the relationship between anxiety exposures and risk of incident dementia, Cox proportional hazard regression models were performed.Results: Taking anxiolytic drugs or having high trait anxiety (STAI score ≥ 44) increased the risk of dementia assessed over 10 years of follow-up [Hazard Ratio (HR) = 1.39, 95%CI: 1.08–1.80, p = 0.01 and HR = 1.26, 95%CI: 1.01–1.57, p = 0.04, respectively], independently of a large panel of socio-demographic variables, health behaviors, cardio-metabolic disorders, and additional age-related disorders such as cardiovascular diseases, activity limitations, and cognitive deficit. However, the associations were substantially attenuated after further adjustment for depressive symptoms.Conclusion: Our findings suggest that depressive symptoms shape the association between anxiety trait and dementia. Further research is needed to replicate our findings and extrapolate our results to anxiety disorders.

【 授权许可】

Unknown