Comparative Analysis of Fasting Blood Glucose and Salivary Electrolytes Concentrations among Individuals with in Type II Diabetes: A Randomized Controlled Hospital Based Study

Toxicology Reports

Evelyn Tarela Ojugbeli¹  Victor Onyemaechi Egboh²  Peggy Ejiro Ohwin²  Tarela Melish Elias Daubry²  Bartholomew Chukwuebuka Nwogueze²  Ofioritse Ogheneyoma Ofulue²  Uchechukwu Levi Osuagwu³  Eze Kingsley Nwangwa⁴ 

[1] Corresponding author.;Department of Human Physiology, Delta State University, Abraka, Nigeria;Department of Medical Biochemistry, Delta State University, Abraka, Nigeria;Translational Health Research Institute (THRI), School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia;

关键词: Diabetes mellitus;    Salivary electrolytes;    Fasting blood glucose;    Nigeria;    Type 2 diabetes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Salivary gland dysfunction is common in people with diabetes. This study aimed to compare the measurements of salivary electrolytes (SE); Na+, K+, Cl- and HCO3- between diabetes and an age matched control group, and assess the relationship between fasting blood glucose (FBG) and salivary electrolytes, and salivary glucose (SG). Eighty-five human participants [diabetes group, n = 45 (23 males and 22 females) and control group, n = 40 (20 males and 20 females)] aged between 25 and 65years were tested. Saliva samples were taken between 7.00 am and 8.00 am after an overnight fast and SG and SE concentrations were analysed. Diabetes mellitus was defined using FBG ≥ 126 mg/dl. SG and SE concentrations were analysed using t-test and Pearson Correlation Coefficient tested the relationship between FBG and Salivary electrolytes and glucose. The participants were matched in their baseline demographic characteristics with a mean age of 49 years (standard deviation SD, 11 years), body mass index (25.7 kg/m2 (SD, 3.6). Half of them were males (50.6 %) and predominantly traders (30.6 %). However, the mean values for the salivary sodium, potassium, chloride and bicarbonate electrolytes were significantly higher in the diabetes group compared with the control group (P < 0.05). Of the salivary electrolytes, only the bicarbonate was significantly correlated with FBG (r = −0.594, p = 0.004) in female participants. This study found that people with diabetes have elevated salivary electrolytes which were not dependent on their age and gender. Although this study suggests some potential for saliva as an alternative in monitoring of diabetes mellitus, extensive research is required before we can reach any firm conclusion.

【 授权许可】

Unknown