Progressive Impairment of Mismatch Negativity Is Reflective of Underlying Pathophysiological Changes in Patients With First-Episode Psychosis

Frontiers in Psychiatry

Wu Jeong Hwang¹  Jihye Park¹  Sun-Young Moon²  Sanghoon Oh²  Minah Kim²  Silvia Kyungjin Lho²  Jun Soo Kwon⁴ 

[1] Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea;Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea;Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea;Institute of Human Behavioral Medicine, SNU-MRC, Seoul, South Korea;

关键词: first-episode psychosis;    mismatch negativity;    event-related potential;    longitudinal change;    pathophysiology;   

DOI  :  10.3389/fpsyt.2020.00587

来源: DOAJ

【 摘 要 】

BackgroundAlthough mismatch negativity (MMN) is associated with the pathophysiology of schizophrenia, whether MMN progressively worsens during the initial years of psychotic disorder has not yet been sufficiently studied. We aimed to investigate whether longitudinal reduction of MMN occurs in patients with first-episode psychosis (FEP) and whether it is reflective of change in cognitive functioning or clinical status.MethodsMMN and the clinical status of 25 patients with FEP were measured and the Trail Making Test (TMT) was administered at baseline and reassessed after 1 year of usual treatment. The MMN of 25 matched healthy controls (HCs) was measured at baseline. Repeated-measures analysis of variance was used to compare MMNs at baseline among the groups, and paired t-test was utilized to compare the baseline and 1-year MMN amplitudes of FEP patients. To identify the association between changes in MMN and changes in cognitive, symptomatic, or functional status over 1 year, multiple regression analysis was used to control for other possible confounders.ResultsMMN amplitudes at baseline were significantly attenuated in FEP patients compared to those in HC. The 1-year follow-up MMN amplitude decreased significantly at the Fz electrode site in the FEP group. Additionally, the decreased MMN amplitude significantly correlated with worsened TMT part B (TMT-B) performance over 1 year but did not correlate with symptomatic or functional improvement.ConclusionsFEP patients with an MMN amplitude reduction showed worsening of cognitive functioning, which might reflect pathophysiological progression during the early years of a psychotic episode.

【 授权许可】

Unknown