LRP4 is required for the olfactory association task in the piriform cortex

Cell & Bioscience

Mingtao Xiong¹  Shunqi Wang¹  Jiang Chen¹  Dong Lin¹  Erkang Fei¹  Dongyan Ren¹  Yongqiang Wu¹  Peng Chen¹  Xinsheng Lai¹  Ziyang Liu¹  Suqi Zou¹  Min Yan¹  Hang Zhang² 

[1] Laboratory of Synaptic Development and Plasticity, Institute of Life Science and School of Life Sciences, Nanchang University;Queen Mary School, Nanchang University;

关键词: LRP4;    Piriform cortex;    Olfactory function;    Golgi staining;    Spine density;   

DOI  :  10.1186/s13578-022-00792-9

来源: DOAJ

【 摘 要 】

Abstract Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long-term potentiation (LTP). Results In this study, we found that Lrp4 was highly expressed in layer II of the piriform cortex. Both body weight and brain weight decreased in Lrp4 ECD/ECD mice without TMD (Transmembrane domain) and ICD (intracellular domain) of LRP4. However, in the piriform cortical neurons of Lrp4 ECD/ECD mice, the spine density increased, and the frequency of both mEPSC (miniature excitatory postsynaptic current) and sEPSC (spontaneous excitatory postsynaptic current) was enhanced. Intriguingly, finding food in the buried food-seeking test was prolonged in both Lrp4 ECD/ECD mice and Lrp4 cKO (conditional knockout of Lrp4 in the piriform cortex) mice. Conclusions This study indicated that the full length of LRP4 in the piriform cortex was necessary for maintaining synaptic plasticity and the integrity of olfactory function.

【 授权许可】

Unknown