Protective Effect of Tomato-Oleoresin Supplementation on Oxidative Injury Recoveries Cardiac Function by Improving β-Adrenergic Response in a Diet-Obesity Induced Model

Antioxidants

Alessandra Altomare¹  Giancarlo Aldini¹  FabianeValentini Francisqueti-Ferron²  DijonHenrique Salomé de Campos²  Fernando Moreto²  Luciana Ghiraldeli²  AnaLucia A. Ferreira²  ArturJunio Togneri Ferron²  CarolCristina Vágula de Almeida Silva²  SilmeiaGarcia Zanati Bazan²  JéssicaLeite Garcia²  KoodyAndre Hassemi Kitawara²  CamilaRenata Correa² 

[1] Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy;Medical School, Sao Paulo State University (Unesp), Botucatu 18618-687, Brazil;

关键词: high sugar-fat diet;    obesity;    β-adrenergic system;    cardiac dysfunction;    lycopene;    tomato-oleoresin;   

DOI  :  10.3390/antiox8090368

来源: DOAJ

【 摘 要 】

The system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly divided into two experimental groups to receive either the control diet (Control, n = 20) or a high sugar-fat diet (HSF, n = 20) for 20 weeks. Once cardiac dysfunction was detected by echocardiogram in the HSF group, animals were re- divided to begin the treatment with Tomato-oleoresin or vehicle, performing four groups: Control (n = 6); (Control + Ly, n = 6); HSF (n = 6) and (HSF + Ly, n = 6). Tomato oleoresin (10 mg lycopene/kg body weight (BW) per day) was given orally every morning for a 10-week period. The analysis included nutritional and plasma biochemical parameters, systolic blood pressure, oxidative parameters in plasma, heart, and cardiac analyses in vivo and in vitro. A comparison among the groups was performed by two-way analysis of variance (ANOVA). Results: The HSF diet was able to induce obesity, insulin-resistance, cardiac dysfunction, and oxidative damage. However, the tomato-oleoresin supplementation improved insulin-resistance, cardiac remodeling, and dysfunction by improving the β-adrenergic response. It is possible to conclude that tomato-oleoresin is able to reduce the oxidative damage by improving the system’s β-adrenergic response, thus recovering cardiac function.

【 授权许可】

Unknown