Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—from the Energy Converters to Biological Activity

Polymers

Anna Tomaszewska¹  Robert Pązik¹  Krzysztof Marycz²  Monika Marędziak²  Magdalena Kulpa-Greszta³  Małgorzata Gazińska⁴  Emilia Zachanowicz⁴ 

[1] Department of Biotechnology, Institute of Biology and Biotechnology, College of Natural Sciences, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland;Faculty of Biology, University of Environmental and Life Sciences Wroclaw, Kożuchowska 5b, 50-631 Wroclaw, Poland;Faculty of Chemistry, Rzeszow University of Technology, Aleja Powstańców Warszawy 12, 35-959 Rzeszow, Poland;Polymer Engineering and Technology Division, Wroclaw University of Technology, 50-370 Wrocław, Poland;

关键词: ferrites;    polyrhodanine;    binary hybrids;    energy conversion;    biological activity;   

DOI  :  10.3390/polym12122934

来源: DOAJ

【 摘 要 】

The PRHD@MnFe₂O₄ binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe₂O₄ was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe₂O₄ hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field.

【 授权许可】

Unknown