Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities

Journal of Clinical Medicine

Joanna Kuźmińska¹  Bartosz Maćkowiak¹  Martyna Ciesielska¹  Maria Kucza¹  Elżbieta Niechciał¹  Przemysław Beik¹  Alicja Kurczewska¹ 

[1] Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, Poland;

关键词: type 1 diabetes;    autoimmune diseases;    prevention;    beta-cell function;    clinical trials;   

DOI  :  10.3390/jcm9092805

来源: DOAJ

【 摘 要 】

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta-cells in the pancreas, caused by the interplay of genetic and environmental factors. Despite the introduction of advanced technologies for diabetes management, most patients fail to achieve target glycemic control, and T1D still has a high burden of long-term end-organ complications. Over several decades, multiple clinical trials have attempted to find prevention for T1D in at-risk individuals or to stabilize, ultimately reverse, the disease in those with T1D. To date, T1D remains yet incurable condition; however, recently improved understanding of the natural history of the disease may lead to new strategies to preserve or improve beta-cell function in those at increased risk and T1D patients. This publication aims to provide an overview of past experiences and recent findings in the prevention of T1D.

【 授权许可】

Unknown