Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo

Nano-Micro Letters

Huiling Gao¹  Shuai Wang²  Wanglinhan Zhang²  Lili Xing²  Xinyu Xue²  Linlin Zhang²  Wenyan Yang² 

[1] College of Life and Health Sciences, Northeastern University;College of Sciences, Northeastern University;

关键词: Diabetes;    Biosensor;    Electronic-skin;    Self-powered;    Glucose detection;    Implantable electronics;   

DOI  :  10.1007/s40820-017-0185-x

来源: DOAJ

【 摘 要 】

Abstract Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment.

【 授权许可】

Unknown