Cytoprotective and Antioxidants in Peroxisomal Neurodegenerative Diseases

Proceedings

Ahmed Elshobaky¹  Boubker Nasser²  Mustapha Cherkaoui-Malki²  Claus Jacob²  Dominique Vervandier-Fasseur²  Pierre Andreoletti²  Norbert Latruffe²  Mounia Tahri-Joutey²  Fatima-Ezzahra Saih²  Saad Shaaban³ 

[1] BioPeroxIL laboratory, Université de Bourgogne-Franche Comté, 6, Boulevard Gabriel, 21000 Dijon, France;NutRedOx Network (COST Action CA16112), 1050 Brussels, Belgium;Organic Chemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhorya Street, 35516 Mansoura, Egypt;

关键词: antioxidant;    leukodystrophy;    organoselenides;    peroxisome;    resveratrol;   

DOI  :  10.3390/proceedings2019011033

来源: DOAJ

【 摘 要 】

Several of the peroxisomal neurodegenerative disorders are the consequence of a specific deficiency of an enzyme or a transporter involved in peroxisomal beta-oxidation of very long chain fatty acids [1,2]. One of the hallmarks in these peroxisomal rare neurodegenerative diseases and in other common demyelinating disorders is the accompanying oxidative damage and neuroinflammation [3]. Compelling data indicates that oxidative stress can activate microglia leading to the overproduction of pro-inflammatory molecules [4,5]. Thus, targeting oxidative stress to limit neuroinflammation may open a new pharmacological therapy window for these still incurable devastating peroxisomal diseases. Here, we present different natural (resveratrol) [6] and synthetic (organoselenides) [7] antioxidant compounds for their capacity of scavenging oxidative stress and in the perspective therapeutic use against oxidative damage in peroxisomal disorders.

【 授权许可】

Unknown