Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy

Drug Delivery

Jia-Hui Sun¹  Shan-Shan Qi¹  Shu-Qin Yu¹  Hao-Han Yu² 

[1] College of Life Sciences, Nanjing Normal University;Nanjing DeBioChem Inc;

关键词: combination chemotherapy;    nano drug co-delivery system (ndcds);    multidrug resistance (mdr);    targeting nanoparticles;    drug delivery materials;   

DOI  :  10.1080/10717544.2017.1410256

来源: DOAJ

【 摘 要 】

To achieve superior therapeutic efficacy, the combination chemotherapy using two or more anticancer drugs in clinical practice has been generally accepted as a feasible strategy. On account of the concept of combination chemotherapy, co-delivery of anticancer drugs with nanotechnology gradually becomes a desired strategy and one of the research frontiers on modern drug delivery. In recent years, nano drug co-delivery system (NDCDS), which loads at least two anticancer drugs with different physicochemical and pharmacological properties into a combination delivery system, has achieved rapid development. NDCDS synergistically inhibited the growth of the tumor compared with the free drugs. In this review, we highlighted the current state of co-delivery nanoparticles and the most commonly used nanomaterial, discussed challenges and strategies, and prospect future development.

【 授权许可】

Unknown