BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

Journal of Lipid Research

Heidi R. Kast¹  Andrew M. Anisfeld²  Peter A. Edwards² 

[1] Molecular Biology Institute, University of California, Los Angeles, CA 90095;Departments of Biological Chemistry and Medicine, University of California, Los Angeles, CA 90095;

关键词: bile acids;    oxysterols;    Tangier disease;    sitosterolemia;    ABC transporters;    lipoproteins;   

DOI  :  

来源: DOAJ

【 摘 要 】

During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRα, NR1H3, and LXRβ, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear receptors play in controlling cholesterol, bile acid, lipoprotein and drug metabolism. The current interest in these nuclear receptors is high, in part, because they appear to be promising therapeutic targets for new drugs that have the potential to control lipid homeostasis. In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile acid metabolism but also lipoprotein metabolism, and iii) the regulation of bile acid transport/metabolism in response to bile acid-activated PXR.— Edwards, P. A., H. R. Kast, and A. M. Anisfeld. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 2002. 43: 2–12.

【 授权许可】

Unknown