First Indian report of IncX3 plasmid carrying blaNDM-7 in Escherichia coli from bloodstream infection: potential for rapid dissemination

New Microbes and New Infections

N.K. Devanga Ragupathi¹  R. Gajendiran¹  J.L.K. Daniel¹  B. Veeraraghavan¹  D.P. Muthuirulandi Sethuvel¹  K. Walia² 

[1] Department of Clinical Microbiology, Christian Medical College, Vellore, India;Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India;

关键词: blaNDM-7;    carbapenem resistance;    IncX3;    ST167 Escherichia coli;    whole genome sequencing;   

DOI  :  10.1016/j.nmni.2017.01.012

来源: DOAJ

【 摘 要 】

Enterobacteriaceae with blaNDM-7 is only infrequently observed. Self-transmissible plasmids carrying the blaNDM gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a blaNDM-7-positive Escherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as E. coli ST-167 with IncX3 plasmid carrying blaNDM-7 in addition to blaTEM-1 and blaCMY-42 genes. The identification of IncX3-blaNDM-7 combination is the first report in India where blaNDM-7 is known to cause higher resistance to carbapenems compared to its variants.

【 授权许可】

Unknown