Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

International Journal of Molecular Sciences

You Chen¹  Raghu P. Upender²  Zhikui Wei² 

[1] Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA;Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;

关键词: adipokine;    cardiometabolic disease;    metabolic syndrome;    sleep disorder;    obstructive sleep apnea;   

DOI  :  10.3390/ijms23031706

来源: DOAJ

【 摘 要 】

Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.

【 授权许可】

Unknown