Diagnosis of Glioma Molecular Markers by Terahertz Technologies

Photonics

Sergei Kuznetsov¹  Oleg Shevelev²  Evgeny Zavjalov²  Olga Cherkasova³  Denis Vrazhnov⁴  Alexander Shkurinov⁵  Maria Konnikova⁵  Yuri Kistenev⁶  Chenjun Shi⁷  Yan Peng⁷ 

[1] Analytical and Technological Research Center, Novosibirsk State University, 630090 Novosibirsk, Russia;Federal Research Center “Institute of Cytology and Genetics of the Siberian Branch of the RAS”, 630090 Novosibirsk, Russia;Institute of Laser Physics, Siberian Branch of the RAS, 630090 Novosibirsk, Russia;Institute of Strength Physics and Materials Science, Siberian Branch of the RAS, 634055 Tomsk, Russia;Institute on Laser and Information Technologies, Branch of the Federal Scientific Research Centre “Crystallography and Photonics” of RAS, 140700 Shatura, Russia;Laboratory of Biophotonics, Tomsk State University, 634050 Tomsk, Russia;Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Terahertz Science Cooperative Innovation Center, University of Shanghai for Science and Technology, Shanghai 200093, China;

关键词: brain glioma;    glioma molecular markers;    terahertz spectroscopy;    terahertz imaging;    metamaterials;    machine learning;   

DOI  :  10.3390/photonics8010022

来源: DOAJ

【 摘 要 】

This review considers glioma molecular markers in brain tissues and body fluids, shows the pathways of their formation, and describes traditional methods of analysis. The most important optical properties of glioma markers in the terahertz (THz) frequency range are also presented. New metamaterial-based technologies for molecular marker detection at THz frequencies are discussed. A variety of machine learning methods, which allow the marker detection sensitivity and differentiation of healthy and tumor tissues to be improved with the aid of THz tools, are considered. The actual results on the application of THz techniques in the intraoperative diagnosis of brain gliomas are shown. THz technologies’ potential in molecular marker detection and defining the boundaries of the glioma’s tissue is discussed.

【 授权许可】

Unknown