Maternal and neonatal outcomes in mothers with diabetes mellitus in qatari population

BMC Pregnancy and Childbirth

Manal M. Masri¹  Noimot O. Olayiwola²  Razan M. Masri³  Nada Y. S. Matani³  Lisa J. Langtree⁴  Prem Chandra⁵  Saad Shahbal⁵  Mohammad A. A. Bayoumi⁶  Sunitha D’Souza⁶  Ashraf I. Gad⁶  Ravi Agarwal⁶  Einas E. Elmalik⁶  Mohamed S. Bakry⁷  Mohamed A. Hendaus⁸ 

[1] Al-Ahli Hospital;Corporate Communications Department, Hamad Medical Corporation (HMC);Department of Medical Education, Hamad Medical Corporation (HMC);Medical Records Department, Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC);Medical Research Center, Hamad Medical Corporation (HMC);Neonatal Intensive Care Unit (NICU), Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC);Obstetrics and Gynecology Department, Faculty of Medicine, Fayoum University;Pediatric Department, Sidra Medicine;

关键词: Gestational Diabetes Mellitus;    Women;    Newborn;    Infant of Diabetic Mother;    Qatari;   

DOI  :  10.1186/s12884-021-04124-6

来源: DOAJ

【 摘 要 】

Abstract Background Diabetes Mellitus (DM) is a major cause of maternal, fetal, and neonatal morbidities. Our objective was to estimate the effect of both pre-pregnancy and gestational DM on the growth parameters of newborns in the Qatari population. Methods In this population-based cohort study, we compared the data of neonates born to Qatari women with both pre-pregnancy and gestational diabetes mellitus in 2017 with neonates of healthy non-diabetic Qatari women. Results Out of a total of 17020 live births in 2017, 5195 newborns were born to Qatari women. Of these, 1260 were born to women with GDM, 152 were born to women with pre-pregnancy DM and 3783 neonates were born to healthy non-diabetic (control) women. The prevalence of GDM in the Qatari population in 2017 was 24.25%. HbA1C% before delivery was significantly higher in women with pre-pregnancy DM (mean 6.19 ± 1.15) compared to those with GDM (mean 5.28 ± 0.43) (P <0.0001). The mean birth weight in grams was 3066.01 ± 603.42 in the control group compared to 3156.73 ± 577.88 in infants born to women with GDM and 3048.78 ± 677.98 in infants born to women with pre-pregnancy DM (P <0.0001). There was no statistically significant difference regarding the mean length (P= 0.080), head circumference (P= 0.514), and rate of major congenital malformations (P= 0.211). Macrosomia (Birth weight > 4000 gm) was observed in 2.7% of the control group compared to 4.8% in infants born to women with GDM, and 4.6% in infants born to women with pre-pregnancy DM (P= 0.001). Multivariate logistic regression analysis demonstrated that higher maternal age (adjusted OR 2.21, 95% CI 1.93, 2.52, P<0.0001), obesity before pregnancy (adjusted OR 1.71, 95% CI 1.30, 2.23, P<0.0001), type of delivery C-section (adjusted OR 1.25, 95% CI 1.09, 1.44, P=0.002), and body weight to gestational age LGA (adjusted OR 2.30, 95% CI 1.64, 2.34, P<0.0001) were significantly associated with increased risk of GDM. Conclusion Despite the multi-disciplinary antenatal diabetic care management, there is still an increased birth weight and an increased prevalence of macrosomia among the infants of diabetic mothers. More efforts should be addressed to improve the known modifiable factors such as women's adherence to the diabetic control program. Furthermore, pre-pregnancy BMI was found to be significantly associated with gestational DM, and this is a factor that can be addressed during pre-conceptional counseling.

【 授权许可】

Unknown