Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Gels

Jiacan Su¹  Qin Zhang²  Yinghua Li²  Weikai Chen²  Ziyang Zhou²  Dagui Chen² 

[1] Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China;Institute of Translational Medicine, Shanghai University, Shanghai 200444, China;

关键词: MMP-cleavable peptides;    crosslinking;    hydrogels;    degradation;    bone regeneration;   

DOI  :  10.3390/gels7040199

来源: DOAJ

【 摘 要 】

Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed.

【 授权许可】

Unknown