Nutrients, Mitochondrial Function and Perinatal Health

Nutrients

JonatanA Mendoza-Ortega¹  Guadalupe Estrada-Gutierrez²  Otilia Perichart-Perera³  AmeyalliM Rodríguez-Cano⁴  ClaudiaC Calzada-Mendoza⁴ 

[1] Immunobiochemistry Department, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico;Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Research Division, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico;Nutrition and Bioprogramming Department, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico;Section for Postgraduate Studies and Research, Higher School of Medicine, Instituto Politécnico Nacional, Mexico City 11340, Mexico;

关键词: micronutrients;    macronutrients;    vitamins;    minerals;    diet;    pregnancy;   

DOI  :  10.3390/nu12072166

来源: DOAJ

【 摘 要 】

Mitochondria are active independent organelles that not only meet the cellular energy requirement but also regulate central cellular activities. Mitochondria can play a critical role in physiological adaptations during pregnancy. Differences in mitochondrial function have been found between healthy and complicated pregnancies. Pregnancy signifies increased nutritional requirements to support fetal growth and the metabolism of maternal and fetal tissues. Nutrient availability regulates mitochondrial metabolism, where excessive macronutrient supply could lead to oxidative stress and contribute to mitochondrial dysfunction, while micronutrients are essential elements for optimal mitochondrial processes, as cofactors in energy metabolism and/or as antioxidants. Inadequate macronutrient and micronutrient consumption can result in adverse pregnancy outcomes, possibly through mitochondrial dysfunction, by impairing energy supply, one-carbon metabolism, biosynthetic pathways, and the availability of metabolic co-factors which modulate the epigenetic processes capable of establishing significant short- and long-term effects on infant health. Here, we review the importance of macronutrients and micronutrients on mitochondrial function and its influence on maternal and infant health.

【 授权许可】

Unknown