Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling

Cell Communication and Signaling

Shivangi Pande¹  Robert Friesel¹  Xuehui Yang¹ 

[1] Center for Molecular Medicine, Maine Medical Center Research Institute;

关键词: Sef;    Interleukin-17;    Interleukin-17 receptor D (IL17RD);    Fibroblast growth factor (FGF);    Fibroblast growth factor receptor (FGFR);    Cellular signaling;   

DOI  :  10.1186/s12964-020-00695-7

来源: DOAJ

【 摘 要 】

Abstract Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways . IL17RD was initially described as a feedback inhibitor of fibroblast growth factor (FGF) signaling during zebrafish and frog development. It was subsequently determined to regulate other receptor tyrosine kinase signaling cascades as well as several proinflammatory signaling pathways including Interleukin-17A (IL17A), Toll-like receptors (TLR) and Interleukin-1α (IL1α) in several vertebrate species including humans. This review will provide an overview of IL17RD regulation of signaling pathways and functions with emphasis on regulation of development and pathobiological conditions. We will also discuss gaps in our knowledge about IL17RD function to provide insight into opportunities for future investigation. Video Abstract

【 授权许可】

Unknown