Crystal structure of a mixed solvated form of amoxapine acetate

Acta Crystallographica Section E: Crystallographic Communications

Vishal Raval¹  Iain D. H. Oswald¹  Rajni M. Bhardwaj¹  Alastair J. Florence¹ 

[1] Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland;

关键词: crystal structure;    amoxapine;    oxazepine;    mixed solvate;    hydrogen bonding.;   

DOI  :  10.1107/S2056989014028096

来源: DOAJ

【 摘 要 】

The mixed solvated salt 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate–acetic acid–cyclohexane (2/2/1), C17H17ClN3O+·C2H3O2−·C2H4O2·0.5C6H12, crystallizes with one molecule of protonated amoxapine (AXPN), an acetate anion and a molecule of acetic acid together with half a molecule of cyclohexane. In the centrosymmetric crystal, both enantiomers of the protonated AXPN molecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N—H...O hydrogen bonding in the [010] direction, creating a sheet lying parallel to (100). The acetic acid molecules are linked to the acetate anions via O—H...O hydrogen bonds within the sheets. Within the sheets there are also a number of C—H...O hydrogen bonds present. The cyclohexane solvent molecules occupy the space between the sheets.

【 授权许可】

Unknown