GLP-1 and Underlying Beneficial Actions in Alzheimer’s Disease, Hypertension, and NASH

Frontiers in Endocrinology

Rong-xuan Hua¹  Qiu-Xuan Li¹  Lei Gao²  Yue-Xin Guo³  Jing-Dong Xu⁴  Han Gao⁴  Bo-Ya Wang⁵  Hong-Wei Shang⁶  Xin Lu⁶ 

[1] Clinical Medicine of “5+3” Program, Xuanwu Hospital, Capital Medical University, Beijing, China;Department of Biomedical Informatics, School of Biomedical Engineering. Capital Medical University, Beijing, China;Department of Oral Medicine, Basic Medical College, Capital Medical University, Beijing, China;Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China;Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, China;Morphological Experiment Center, School of Basic Medical Sciences, Capital Medical University, Beijing, China;

关键词: GLP-1;    Alzheimer’s disease;    blood pressure;    DPP-4;    non-alcoholic steatohepatitis;    signaling pathway;   

DOI  :  10.3389/fendo.2021.721198

来源: DOAJ

【 摘 要 】

GLP-1 is derived from intestinal L cells, which takes effect through binding to GLP-1R and is inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). However, GLP-1 possesses broader pharmacological effects including anti-inflammation, neuro-protection, regulating blood pressure (BP), and reducing lipotoxicity. These effects are interconnected to the physiological and pathological processes of Alzheimer’s disease (AD), hypertension, and non-alcoholic steatohepatitis (NASH). Currently, the underlying mechanism of these effects is still not fully illustrated and a better understanding of them may help identify promising therapeutic targets of AD, hypertension, and NASH. Therefore, we focus on the biological characteristics of GLP-1, render an overview of the mechanism of GLP-1 effects in diseases, and investigate the potential of GLP-1 analogues for the treatment of related diseases in this review.

【 授权许可】

Unknown