Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor

Frontiers in Immunology

Cheng Xiao¹  Yuan Xu²  Xiaoxue Cao³  Danping Fan³  Xiaoyu Xi⁴  Xing Wang⁴  Qinbin Ye⁴  Qiong Wang⁴  Mengxiao Zhang⁴ 

[1] Department of Emergency, China-Japan Friendship Hospital, Beijing, China;Department of Traditional Chinese Medicine (TCM) Rheumatology, China-Japan Friendship Hospital, Beijing, China;Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China;Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China;School ofTraditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;

关键词: rheumatoid arthritis;    polycyclic aromatic hydrocarbons;    particulate matter;    aryl hydrocarbon receptor;    aryl hydrocarbon receptor repressor;   

DOI  :  10.3389/fimmu.2022.797815

来源: DOAJ

【 摘 要 】

Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several factors could affect RA, such as mutations in susceptibility genes, epigenetic modifications, age, and race. Recently, environmental factors, particularly polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention in RA pathogenesis. Therefore, exploring the specific mechanisms of PAHs in RA is vitally critical. In this review, we summarize the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA. Additionally, the development of therapeutic drugs that target AHR is also reviewed. Finally, we discuss the challenges and perspectives on AHR application in the future.

【 授权许可】

Unknown