Analysis of PD-1 related immune transcriptional profile in different cancer types

Cancer Cell International

Sihua Wang¹  Wenjie Chen¹  Jun Shang¹  Qian Song²  Zuyi Yang²  Xiaoyan Sun²  Jingcheng Yang²  Meijuan Xue² 

[1] Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;The Genius Medicine Consortium (TGMC);

关键词: PD-1;    PD-1 blockade;    Pan-cancer;    RNA-seq;    Tumor immune environment;    Immunomodulators;   

DOI  :  10.1186/s12935-018-0712-y

来源: DOAJ

【 摘 要 】

Abstract Background Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it’s essential to elicit the PD-1 related immune process in different types of cancer. Methods The Cancer Genome Atlas was used to collect the RNA-seq data of 33 cancer types. The microenvironment cell populations-counter was used to analyze the immune cell infiltrates. KEGG and GO analysis were performed to investigate PD-1 associated biological process. Kaplan–Meier survival curves and Cox’s proportional hazards model were performed for prognostic value analysis. Results We demonstrated that PD-1 expression varied in different cancer types. The uveal melanoma had a low PD-1 expression and poor infiltrated with immune cells. But it showed the strong correlation of PD-1 with the most types of immune cells. The PD-1 demonstrated a robust relationship with other immunomodulators and showed its involvement in critical functions correlated with anti-tumor immune pathways. Survival analysis indicated the PD-1 expression suggested different prognosis in different cancer types. Conclusions Our investigations promote a better understanding of the PD-1 blockade and provide PD-1 related personized combined immunotherapy for different types of cancer patients.

【 授权许可】

Unknown