The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer

Obstetrics & Gynecology Science

Jong Kil Joo¹  Ki Hyung Kim¹  Yun Hwa Kim¹  Seung Chul Kim²  Kyu Sup Lee²  Seul Lee²  Dong Suh Seo² 

[1] Biomedical Research Institute, Pusan National University Hospital, Busan, .Korea;Department of Obstetrics and Gynecology, School of Medicine;

关键词: tamoxifen;    endometrium;    breast neoplasms;    ovary;   

DOI  :  10.5468/ogs.2018.61.5.615

来源: DOAJ

【 摘 要 】

ObjectiveTo evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer.MethodsWe retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination.ResultsWe evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up.ConclusionTamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination.

【 授权许可】

Unknown