Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Antibiotics

Eric Biron¹  Md Ramim Tanver Rahman¹  Ismail Fliss² 

[1] Faculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada;Institute of Nutrition and Functional Foods, Université Laval, Québec, QC G1V 0A6, Canada;

关键词: growth promoters;    alternatives to antibiotics;    poultry production;    swine production;    acidifiers;    bacteriophages;   

DOI  :  10.3390/antibiotics11060766

来源: DOAJ

【 摘 要 】

The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.

【 授权许可】

Unknown