Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study

Journal of Clinical Medicine

Ana Serrador Frutos¹  IgnacioJ. Amat-Santos¹  Tania Rodríguez-Gabella¹  Rodrigo Estevez-Loureiro²  AnaB. Cid Alvarez³  Ramiro Trillo-Nouche³  Amparo Martinez Monzonís³  Valeriano Ruiz-Quevedo⁴  Alberto Berenguer-Jofresa⁵  Xavier Carrillo⁶  Lara Ruiz Gomez⁷  Leire Andraka Ikazuriaga⁷  JoseL. Diez⁸  Ander Regueiro⁹  Manel Sabaté⁹  Xavier Freixa⁹  Angel Sánchez-Recalde^1,10  RosaA. Hernández-Antolín^1,10  Luisa Salido Tahoces^1,10  Manuel Pan^1,11  Dolores Mesa^1,11  Miguel Romero^1,11  Luis Asmarats Serra^1,12  Estafanía Fernández Peregrina^1,12  Dabit Arzamendi^1,12  ChiHion Li^1,12  Juan Sanchis^1,13  MariaR. Ortas-Nadal^1,14  JuanF. Oteo Dominguez^1,15  Eduardo Molina Navarro^1,16  JoseR. López-Mínguez^1,17  Ignacio Cruz-Gonzalez^1,18  Blanca Trejo-Velasco^1,18  Fernando Carrasco-Chinchilla^1,19  JoseM. Hernandez-Garcia^1,19  JuanH. Alonso-Briales^1,19  VictorM. Becerra-Muñoz^1,19  Javier Gualis^2,20  Carmen Garrote-Coloma^2,20  Tomas Benito-Gonzalez^2,20  Felipe Fernández-Vázquez^2,20  Cristobal Urbano-Carrillo^2,21  Gabriela Tirado-Conte^2,22  Pilar Jimenez-Quevedo^2,22  Luis Nombela-Franco^2,22  JoseA. De Agustín^2,22  Rebeca Lorca^2,23  Pablo Avanzas^2,23  Daniel Hernandez-Vaquero^2,23  Cesar Moris^2,23  Isaac Pascual^2,23 

[1] CIBERCV, Cardiology Department, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain;Cardiology Department, Alvaro Cunqueiro University Hospital, 36213 Vigo, Spain;Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, CIBERCV, 15706 Santiago de Compostela, Spain;Cardiology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain;Cardiology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain;Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Barcelona, Spain;Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain;Cardiology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain;Cardiology Department, Institut Clínic Cardiovascular, Hospital Clinic de Barcelona, 08036 Barcelona, Spain;Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain;Cardiology Department, Reina Sofía University Hospital, University of Córdoba (IMIBIC), 14004 Córdoba, Spain;Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain;Cardiology Department, University Clinic Hospital of Valencia, University of Valencia, INCLIVA, CIBERCV, 46010 Valencia, Spain;Cardiology Department, University Hospital Miguel Servet, 50009 Zaragoza, Spain;Cardiology Department, University Hospital Puerta de Hierro/Majadahonda, 28222 Madrid, Spain;Cardiology Department, University Hospital Virgen de las Nieves, 18014 Granada, Spain;Cardiology Department, University Hospital of Badajoz, 06080 Badajoz, Spain;Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 Salamanca, Spain;Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain;Cardiology Department. University Hospital of León, 24008 León, Spain;Cardiology Department., Complejo Hospital Regional Universitario de Málaga, 29010 Málaga, Spain;Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain;Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain;

关键词: Mitraclip;    functional mitral regurgitation;    transcatheter;    left ventricular ejection Fraction;   

DOI  :  10.3390/jcm9061792

来源: DOAJ

【 摘 要 】

Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip^® between two groups according to LVEF. Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was the combined one-year all-cause mortality and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF. Results: Among 535 FMR eligible patients, 144 patients with LVEF <30% (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups. Conclusion: FMR patients with LVEF <30% treated with MitraClip^® had higher mortality and readmissions than patients with LVEF ≥30% treated with the same device. However, both groups improved the NYHA functional class and MR severity.

【 授权许可】

Unknown