One Raft to Guide Them All, and in Axon Regeneration Inhibit Them

International Journal of Molecular Sciences

Ramón Martínez-Mármol¹  Cristina Roselló-Busquets²  Marc Hernaiz-Llorens²  Eduardo Soriano² 

[1] Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia Campus, Brisbane, QLD 4072, Australia;Department of Cell Biology, Physiology and Immunology, Faculty of Biology and Institute of Neurosciences, University of Barcelona, 08028 Barcelona, Spain;

关键词: axonal regeneration;    lipid rafts;    cholesterol;    sphingolipid;    CNS injury;    neurodegeneration;   

DOI  :  10.3390/ijms22095009

来源: DOAJ

【 摘 要 】

Central nervous system damage caused by traumatic injuries, iatrogenicity due to surgical interventions, stroke and neurodegenerative diseases is one of the most prevalent reasons for physical disability worldwide. During development, axons must elongate from the neuronal cell body to contact their precise target cell and establish functional connections. However, the capacity of the adult nervous system to restore its functionality after injury is limited. Given the inefficacy of the nervous system to heal and regenerate after damage, new therapies are under investigation to enhance axonal regeneration. Axon guidance cues and receptors, as well as the molecular machinery activated after nervous system damage, are organized into lipid raft microdomains, a term typically used to describe nanoscale membrane domains enriched in cholesterol and glycosphingolipids that act as signaling platforms for certain transmembrane proteins. Here, we systematically review the most recent findings that link the stability of lipid rafts and their composition with the capacity of axons to regenerate and rebuild functional neural circuits after damage.

【 授权许可】

Unknown