Rapid Hemostatic Biomaterial from a Natural Bath Sponge Skeleton

Marine Drugs

Guoliang Yan¹  Qinghua Wang²  Jing Zhao²  Jun Chen²  Jingwei Chen²  Ming Chen²  Dexiang Wang²  Huilong Ou²  Minghui Shen³ 

[1] Basic Medical Department of School of Medicine, Xiamen University, Xiamen 361102, China;Department of Marine Biological Science & Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China;Hainan Academy of Ocean and Fisheries Sciences, Haikou 570206, China;

关键词: Spongia officinalis;    spongin;    hemostasis;    platelet;    biocompatibility;   

DOI  :  10.3390/md19040220

来源: DOAJ

【 摘 要 】

Uncontrolled bleeding is the main cause of mortality from trauma. Collagen has been developed as an important hemostatic material due to its platelet affinity function. A bath sponge skeleton is rich in collagen, also known as spongin. To understand the hemostatic effect of spongin, spongin materials, SX, SFM and SR were prepared from the bath sponge Spongia officinalis, and hemostatic experiments were performed. The SX, SFM and SR were significantly better than the positive control, type I collagen, in shortening the whole blood clotting time in vitro and hemostasis upon rat tail amputation. In a hemostatic experiment of rabbit common carotid artery injury, the hemostatic time and 3 h survival rate of the SFM group were 3.00 ± 1.53 min and 100%, respectively, which are significantly better than those of the commercial hemostat CELOX-A (10.33 ± 1.37 min and 67%, respectively). Additionally, the SFM showed good coagulation effects in platelet-deficient blood and defibrinated blood, while also showing good biocompatibility. Through a variety of tests, we speculated that the hemostatic activity of the SFM is mainly caused by its hyperabsorbency, high affinity to platelets and high effective concentration. Overall, the SFM and spongin derivates could be potential hemostatic agents for uncontrolled bleeding and hemorrhagic diseases caused by deficiency or dysfunction of coagulation factors.

【 授权许可】

Unknown