The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial

Nutrients

Alexandra L. McCarthy¹  Elisabeth Isenring²  Anna Lohning²  Wolfgang Marx²  Karin Ried³  Avni Sali³  Dan McKavanagh⁴  Luis Vitetta⁵ 

[1] Division of Cancer Services, Princess Alexandra Hospital, and Institute of Health and Biomedical Innovation, Brisbane, QLD 4102, Australia;Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4226, Australia;National Institute of Integrative Medicine, Melbourne, VIC 3122, Australia;School of Nursing, University of Auckland, Auckland 1010, New Zealand;Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia;

关键词: ginger;    nausea;    CINV;    dietary supplements;    cancer;    emesis;   

DOI  :  10.3390/nu9080867

来源: DOAJ

【 摘 要 】

Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic factors. Over three consecutive chemotherapy cycles, nausea was more prevalent than vomiting (47% vs. 12%). In chemotherapy Cycle 1, intervention participants reported significantly better QoL related to CIN (p = 0.029), chemotherapy-induced nausea and vomiting (CINV)-related QoL (p = 0.043), global QoL (p = 0.015) and less fatigue (p = 0.006) than placebo participants. There were no significant results in Cycle 2. In Cycle 3, global QoL (p = 0.040) and fatigue (p = 0.013) were significantly better in the intervention group compared to placebo. This trial suggests adjuvant ginger supplementation is associated with better chemotherapy-induced nausea-related quality of life and less cancer-related fatigue, with no difference in adverse effects compared to placebo.

【 授权许可】

Unknown