What Should Health Departments Do with HIV Sequence Data?

Viruses

Ethan Romero-Severson¹  Arshan Nasir¹  Thomas Leitner¹ 

[1] Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA;

关键词: HIV epidemic;    public health;    molecular surveillance;    phylogenetics;    transmission reconstruction;   

DOI  :  10.3390/v12091018

来源: DOAJ

【 摘 要 】

Many countries and US states have mandatory statues that require reporting of HIV clinical data including genetic sequencing results to the public health departments. Because genetic sequencing is a part of routine care for HIV infected persons; health departments have extensive sequence collections spanning years and even decades of the HIV epidemic. How should these data be used (or not) in public health practice? This is a complex; multi-faceted question that weighs personal risks against public health benefit. The answer is neither straightforward nor universal. However; to make that judgement—of how genetic sequence data should be used in describing and combating the HIV epidemic—we need a clear image of what a phylogenetically enhanced HIV surveillance system can do and what benefit it might provide. In this paper, we present a positive case for how up-to-date analysis of HIV sequence databases managed by health departments can provide unique and actionable information of how HIV is spreading in local communities. We discuss this question broadly, with examples from the US, as it is globally relevant for all health authorities that collect HIV genetic data.

【 授权许可】

Unknown