Histone variant H3.3 and its future prospects in cancer clinic

Journal of Radiation and Cancer Research

关键词: Cancer;    DNA damage;    epigenome;    mutation;    oncohistone;   

DOI  :  10.4103/jrcr.jrcr_4_17

来源: DOAJ

【 摘 要 】

Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its canonical counterparts H3.1/3.2. Second, H3.3 has been consistently associated with an active state of chromatin. Apart from this function research in the past few years has also revealed that H3.3 has a central role to play in maintaining the somatic cell identity, for efficient ultraviolet induce DNA damage repair and proper segregation of chromosomes during cell division. Further, the discovery of “driver mutations” on this variant has bought it to limelight in cancer biology to the extent that “oncohistone,” a new term has been coined for different mutants of H3.3. Here, we review the functional importance of H3.3 in the context of cancer.

【 授权许可】

Unknown