Pro-osteogenesis and in vivo tracking investigation of a dental implantation system comprising novel mTi implant and HYH-Fe particles

Bioactive Materials

Qin Zou¹  Juan Wu¹  Ling Zou¹  Wei Li²  Danxue Li³  Xiyu Li³  Yi Man³ 

[1] National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China;Analytical and Testing Center, Sichuan University, Chengdu, 610064, China;;State Key Laboratory of Oral Diseases &

关键词: Pro-osteogenesis;    mTi implant;    Local static magnetic field;    Superparamagnetic particles;    In vivo tracking;   

DOI  :  

来源: DOAJ

【 摘 要 】

Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants. To promote early osteogenesis, we first designed a Ti dental implant with a built-in magnet (mTi) to produce a local static magnetic field (SMF). Then, a dental implantation system comprising the mTi implant and the superparamagnetic hydroxyapatite (HA:Yb/Ho–Fe, named HYH-Fe) particles was implanted into the alveolar bone of beagles. The results showed that the mTi + HYH-Fe group displayed better early osteogenesis and later stage osseointegration than the Ti + HA and mTi + HA groups. A combination of the local SMF (mTi) and superparamagnetic HYH-Fe particles had a positive effect on the pro-osteogenesis of Ti implants. The results also indicated that week 10 could be adopted as the key time point to evaluate the early osteogenic effect of the mTi + HYH-Fe implantation system, which would be a promising prospect for promotion of osteogenesis, in vivo tracking investigation of material-bone relationships, and clinical applications.

【 授权许可】

Unknown