Could Iron-Nitrogen Doping Modulate the Cytotoxicity of TiO2 Nanoparticles?

Nanomaterials

Anca Dinischiotu¹  Miruna S. Stan¹  Ionela Cristina Nica¹  Bogdan Andrei Miu¹  Lucian Diamandescu² 

[1] Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania;National Institute of Materials Physics (NIMP), Atomistilor 405A, Magurele, 077125 Bucharest, Romania;

关键词: titanium dioxide;    P25 Degussa nanoparticles;    iron doping;    photocatalysts;    human cytotoxicity;   

DOI  :  10.3390/nano12050770

来源: DOAJ

【 摘 要 】

Titanium dioxide nanoparticles (TiO₂ NPs) are found in several products on the market that include paints, smart textiles, cosmetics and food products. Besides these, TiO₂ NPs are intensively researched for their use in biomedicine, agriculture or installations to produce energy. Taking into account that several risks have been associated with the use of TiO₂ NPs, our aim was to provide TiO₂ NPs with improved qualities and lower toxicity to humans and the environment. Pure TiO₂ P25 NPs and the same NPs co-doped with iron (1%) and nitrogen atoms (P25-Fe(1%)-N NPs) by hydrothermal treatment to increase the photocatalytic activity in the visible light spectrum were in vitro evaluated in the presence of human lung cells. After 24 and 72 h of incubation, the oxidative stress was initiated in a time- and dose-dependent manner with major differences between pure P25 and P25-Fe(1%)-N NPs as revealed by malondialdehyde and reactive oxygen species levels. Additionally, a lower dynamic of autophagic vacuoles formation was observed in cells exposed to Fe-N-doped P25 NPs compared to the pure ones. Therefore, our results suggest that Fe-N doping of TiO₂ NPs can represent a valuable alternative to the conventional P25 Degussa particles in industrial and medical applications.

【 授权许可】

Unknown