Decreased Cerebral Blood Flow and Delayed Arterial Transit Are Independently Associated With White Matter Hyperintensity

Frontiers in Aging Neuroscience

Min Lou¹  Yao Zhang²  Xinfeng Yu²  Shuyue Wang²  Yeerfan Jiaerken²  Minming Zhang²  Hui Hong²  Ruiting Zhang²  Peiyu Huang² 

[1] Department of Neurology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China;Department of Radiology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China;

关键词: cerebral blood flow;    arterial transit;    white matter hyperintensities;    lacunes;    cerebral small vessel disease;   

DOI  :  10.3389/fnagi.2022.762745

来源: DOAJ

【 摘 要 】

AimWhite matter hyperintensities (WMH) and lacunes were important features of cerebral small vessel disease (CSVD), which contributes to 25% of ischemic strokes and 45% of dementias. Currently, the underlying mechanisms of WMH and lacunes are not clear, and the role of hemodynamic changes is not fully investigated. In this study, we aimed to measure the cerebral blood flow (CBF) and arterial transit in CSVD patients and to investigate their association with WMH and lacunes.MethodsWe retrospectively analyzed the prospectively collected database of CSVD patients. Ninety-two CSVD patients with complete imaging data were included. We used arterial spin labeling (ASL) with post-labeling delay time (PLD) of 1,525 ms and 2,025 ms to measure CBF respectively, and the difference between CBFPLD1.5 and CBFPLD2.0 was recorded as δCBF. We performed regression analysis to understand the contribution of CBF, δCBF to CSVD imaging markers.ResultsWe found that CBF derived from both PLDs was associated with WMH volume and the presence of lacune. CBFPLD1.5 was significantly lower than CBFPLD2.0 in CSVD patients, and δCBF was correlated with WMH volume but not the presence of lacune. Furthermore, CBFPLD2.0 and δCBF were both associated with WMH in multiple regression analyses, suggesting an independent effect of delayed arterial transit. On an exploratory basis, we also investigated the relationship between venous disruption on δCBF, and we found that δCBF correlated with deep medullary veins score.ConclusionBoth CBF and arterial transit were associated with WMH. ASL with multiple PLDs could provide additional hemodynamic information to CSVD-related studies.

【 授权许可】

Unknown