Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety

iScience

Gona Choi¹  Dajin Cho²  Sungchil Yang²  Minseok Lee³  Sojeong Pak³  Lee Wei Lim³  Jaydeep Roy³  Sunggu Yang⁴  Jinho Lee⁵  Shaowen Bao⁵  Chi Him Poon⁵ 

[1] Corresponding author;Department of Nano-Bioengineering, Incheon National University, Incheon 22012, South Korea;Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China;Department of Physiology, University of Arizona, Tucson, AZ 85724, USA;School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China;

关键词: Biological sciences;    Neuroscience;    Behavioral neuroscience;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Anxiety is characteristic comorbidity of noise-induced hearing loss (NIHL), which causes physiological changes within the dentate gyrus (DG), a subfield of the hippocampus that modulates anxiety. However, which DG circuit underlies hearing loss-induced anxiety remains unknown. We utilize an NIHL mouse model to investigate short- and long-term synaptic plasticity in DG networks. The recently discovered longitudinal DG-DG network is a collateral of DG neurons synaptically connected with neighboring DG neurons and displays robust synaptic efficacy and plasticity. Furthermore, animals with NIHL demonstrate increased anxiety-like behaviors similar to a response to chronic restraint stress. These behaviors are concurrent with enhanced synaptic responsiveness and suppressed short- and long-term synaptic plasticity in the longitudinal DG-DG network but not in the transverse DG-CA3 connection. These findings suggest that DG-related anxiety is typified by synaptic alteration in the longitudinal DG-DG network.

【 授权许可】

Unknown