Synchronously Amplified Photoacoustic Image Recovery (SAPhIRe)

Photoacoustics

Donald VanderLaan¹  Stanislav Emelianov²  Aida A. Demissie³  Robert M. Dickson³  Md S. Islam⁴ 

[1] Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA;Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA;;School of Chemistry &;School of Electrical &

关键词: Modulation;    Multimodal;    Spectroscopy;    Signal processing;    Imaging;    Fluorescence;   

DOI  :  

来源: DOAJ

【 摘 要 】

In molecular and cellular photoacoustic imaging with exogenous contrast agents, image contrast is plagued by background resulting from endogenous absorbers in tissue. By using optically modulatable nanoparticles, we develop ultra-sensitive photoacoustic imaging by rejecting endogenous background signals and drastically improving signal contrast through time-delayed pump-probe pulsed laser illumination. Gated by prior pump excitation, modulatable photoacoustic (mPA) signals are recovered from unmodulatable background through simple, real-time image processing to yield background-free photoacoustic signal recovery within tissue mimicking phantoms and from ex-vivo tissues. Inherently multimodal, the fluorescence and mPA sensitivity improvements demonstrate the promise of Synchronously Amplified Photoacoustic Image Recovery (SAPhIRe) for PA imaging in diagnosis and therapy.

【 授权许可】

Unknown