Gender Differences and Quality of Life in Parkinson’s Disease

International Journal of Environmental Research and Public Health

Immacolata Ambrosino¹  Antonio Biondi²  Marco Vacante²  Elena Barbagelata³  Miriam Gino⁴  Cecilia Politi⁵  Marina Marranzano⁶  Tiziana Ciarambino⁷  Rosalia Ragusa⁸  Pietro Crispino⁹ 

[1] ASL Bari, DSS 13, 70023 Bari, Italy;Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy;Department of Internal Medicine, ASL 4 Chiavarese, Sestri Levante Hospital, 16039 Sestri Levante (GE), Italy;Department of Internal Medicine, Rivoli Hospital, 10098 Rivoli (TO), Italy;Department of Internal Medicine, Veneziale Hospital, 86170 Isernia, Italy;Department of Medical, Surgical and Advanced Sciences, University of Catania, 95123 Catania, Italy;Department of Medical, Surgical, Neurological, Metabolic and Geriatrics Sciences, Marcianise Hospital, ASL Caserta, University of Campania “L. Vanvitelli”, 81025 Naples, Italy;Health Technology Assessment Committee, University Hospital G. Rodolico, 95123 Catania, Italy;Internal Medicine Department, Lagonegro Hospital, 85042 Lagonegro (PZ), Italy;

关键词: Parkinson’s disease;    gender;    dopamine;    levodopa;    quality of life;   

DOI  :  10.3390/ijerph18010198

来源: DOAJ

【 摘 要 】

Parkinson’s disease has been found to significantly affect health-related quality of life. The gender differences of the health-related quality of life of subjects with Parkinson’s disease have been observed in a number of studies. These differences have been reported in terms of the age at onset, clinical manifestations, and response to therapy. In general, women with Parkinson’s disease showed more positive disease outcomes with regard to emotion processing, non-motor symptoms, and cognitive functions, although women report more Parkinson’s disease-related clinical manifestations. Female gender predicted poor physical functioning and socioemotional health-related quality of life, while male gender predicted the cognitive domain of health-related quality of life. Some studies reported gender differences in the association between health-related quality of life and non-motor symptoms. Depression and fatigue were the main causes of poorer health-related quality of life in women, even in the early stages of Parkinson’s disease. The aim of this review was to collect the best available evidence on gender differences in the development of Parkinson’s disease symptoms and health-related quality of life.

【 授权许可】

Unknown