Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

Cells

Qingfeng Chen¹  Kylie Su Mei Yong¹  Zhisheng Her¹ 

[1] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore 138673, Singapore;

关键词: humanized mice;    hepatitis C virus;    liver;    hepatotropic disease;    steatosis;    cirrhosis;    hepatocellular carcinoma;   

DOI  :  10.3390/cells8060604

来源: DOAJ

【 摘 要 】

Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effective therapeutics and vaccines. In this context, we will focus our discussion on humanized mice in HCV research. Here, these humanized mice are defined as animal models that encompass either only human hepatocytes or both human liver and immune cells. Aspects related to immunopathogenesis, anti-viral interventions, drug testing and perspectives of these models for future HCV research will be discussed.

【 授权许可】

Unknown