Synthesis of 4-Arylselanyl-1H-1,2,3-triazoles from Selenium-Containing Carbinols

Molecules

Francesca Begini¹  Claudio Santi¹  EricF. Lopes²  EderJoão Lenardão²  RenataA. Balaguez²  Diego Alves²  Allya Larroza² 

[1] Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences University of Perugia Via del Liceo 1, 06123 Perugia, Italy;LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil;

关键词: selenium;    1,2,3-triazoles;    click chemistry;    cycloaddition;    carbinols;    heterocycles;   

DOI  :  10.3390/molecules26082224

来源: DOAJ

【 摘 要 】

In this work, we present a simple way to achieve 4-arylselanyl-1H-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols were used as starting materials to produce a range of selanyl-triazoles in moderate to good yields, including a quinoline and Zidovudine derivatives. One-pot protocols are crucial to the current concerns about waste production and solvent consumption, avoiding the isolation and purification steps of the reactive terminal selanylalkynes. We could also isolate an interesting and unprecedented by-product with one alkynylselenium moiety connected to the triazole.

【 授权许可】

Unknown