Chronic adult T-cell Leukemia in a young male after blood transfusion as a newborn

International Journal of Cancer Therapy and Oncology

Nora Halperin¹  Francisca Rojas¹  Magali Colucci²  Alejandra Altube³  Alberto Deves⁴  Cecilia Cabral Lorenzo⁵  Olivier Hermine⁶  Mirna Biglione⁷  Camila Cánepa⁷  Matías Ruggieri⁷  Carolina Berini⁷ 

[1]Departmentof HaematologyHospital de Clínicas “José de San Martín”

[2]Departmentof Haematology, Hospital de Clínicas “José de San Martín”

[3]Departmentof Haematology. Hospital de Clínicas “José de San Martín”

[4]Departmentof PathologyHospital de Clínicas “José de San Martín”

[5]Departmentof pathologyHospital de Clínicas “José de San Martín”

[6]Department of Hematology INSERM U1163 and CNRS ERL8654, Imagine Institute, Necker Hospital, Assistance publique des hôpitaux de Paris, Paris Descartes University, 75473 Paris Cedex 15

[7]Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, UBA-CONICET.

关键词: ATLL, Chronic, HTLV-1, Blood transfusion, Latency;   

DOI  :  10.14319/ijcto.42.8

来源: DOAJ

【 摘 要 】

Human T-cell Lymphotropic virus type 1 (HTLV-1) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HTM/TSP). Areas of extremely high HTLV-1 prevalence are surrounded by areas of middle or very low prevalence. ATLL is an aggressive lymphoproliferative malignancy of peripheral T cells, with an incidence of less than 5% in HTLV-1-infected individuals. ATLL developed in the majority of cases in individuals who were infected with HTLV-1 by their mothers due to prolonged breastfeeding. In non-endemic areas, ATLL is usually limited to immigrants, their sexual partners and descendants from endemic regions. Very few cases of ATLL have been diagnosed in recipient patients few years after an organ transplantation or blood transfusion worldwide. Achieving an accurate and fast diagnosis of ATLL can be challenging due to the lack of professional experience, delayed consultation and difficulty in its sub-classification. We present a case of a delayed onset of a chronic ATLL in an 18-years-old male who was transfused with blood components as a premature newborn in Buenos Aires, a non-endemic city of South America.

【 授权许可】

Unknown