Association between Lipid Profiles and the Incidence of Hepatocellular Carcinoma: A Nationwide Population-Based Study

Cancers

Yuri Cho¹  Sang-Hyun Park²  Kyungdo Han²  DongWook Shin³  Su-Min Jeong⁴  Jeong-Ju Yoo⁵  Young Chang⁶  EunJu Cho⁷  SuJong Yu⁷  GohEun Chung⁸ 

[1] Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang 10408, Korea;Department of Biostatistics, College of Medicine, The Soongsil University, Seoul 06978, Korea;Department of Family Medicine, Samsung Medical Center Supportive Care Center, Samsung Comprehensive Cancer Center, Seoul 06351, Korea;Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea;Department of Gastroenterology and Hepatology, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Korea;Department of Gastroenterology and Hepatology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea;Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;Department of Internal Medicine, Healthcare Research Institute, Gangnam Healthcare Center, Seoul National University Hospital, Seoul 06236, Korea;

关键词: cholesterol;    low-density lipoprotein;    hepatocellular carcinoma;    lipid metabolism;   

DOI  :  10.3390/cancers13071599

来源: DOAJ

【 摘 要 】

Background and Aims: Altered lipid metabolism has been implicated in the development of hepatocellular carcinoma (HCC). This study investigated the relationships between lipid profiles and HCC development. Methods: Data were obtained from the Korean National Health Insurance Service from 2009 to 2017. Cox regression analysis was used to examine the hazard ratios of HCC in 8,528,790 individuals who had undergone health check-ups in 2009. Results: During a median of 7.3 years follow-up, 26,891 incidents of HCCs were identified. The incidence of HCC (per 100,000 person-years) gradually decreased according to the increase in total-cholesterol and LDL-cholesterol; the incidence of HCC was 69.2, 44.0, 33.9, and 25.8 in quartile-1 (Q1), Q2, Q3, and Q4 population of total-cholesterol, and 63.6, 44.5, 37.2, and 28.3 in Q1, Q2, Q3, and Q4 population of LDL-cholesterol, respectively. Compared to Q1 of total-cholesterol, subjects in higher total-cholesterol levels were associated with a lower incidence of HCC (multiple covariates-adjusted hazard ratio (aHR): Q2 0.61; Q3 0.46; Q4 0.36). These associations were consistently observed in stratified subgroup analysis by the presence of liver cirrhosis or viral hepatitis. Conclusions: Low serum lipid levels were significantly associated with the increased risk of developing HCC. A low lipid profile might be an independent risk factor and preclinical marker for HCC.

【 授权许可】

Unknown