Novel isochroman-triazoles and thiadiazole hybrids: Design, synthesis and antimicrobial activity

Journal of Saudi Chemical Society

Aamer Saeed¹  Amara Mumtaz¹ 

[1] Department of Chemistry, Quaid-I-Azam University, 45320 Islamabad, Pakistan;

关键词: Isochromanyl triazoles;    Thiadiazoles;    Antimicrobial activity;   

DOI  :  10.1016/j.jscs.2015.04.004

来源: DOAJ

【 摘 要 】

In this study, new isochroman-triazole (6a–e) and thiadiazole (7a–e) conjugates were obtained by heterocyclization of isochromanyl thiosemicarbazides (5a–e) under basic and acidic catalysis respectively. The latter were obtained by the treatment of corresponding acetohydrazide (4) with suitably substituted phenylisothiocyanates. The acetohydrazide (4) is accessible from methyl 2-(6,7,8-trimethoxy-1-methyl-3,4-dihydro-1H-isochromen-1-yl)acetate (3) obtainable by oxa-Pictet–Spengler reaction of 2-(3,4,5-trimethoxyphenyl)ethanol (2) with methyl acetoacetate in the presence of p-TsOH. The isochromanyl triazoles (6a–e) and isochromanyl thiadiazoles (7a–e) were screened for their in vitro antibacterial activity against four bacterial strains and were found to exhibit moderate to good activity toward the tested microorganisms, compared to ampicillin, the standard drug. In vitro antifungal activity was also determined against four fungal strains using fluconazole as standard and the most active compounds were identified in each case.

【 授权许可】

Unknown