Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System

Frontiers in Physiology

Nobuaki Fukuma¹  Yusuke Adachi¹  Masaki Hashimoto¹  Hiroyuki Tokiwa¹  Akira Otani¹  Masayuki Toyoda¹  Kazutaka Ueda¹  Genri Numata¹  Pang-Yen Liu¹  Eiki Takimoto² 

[1] Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyô, Japan;Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States;

关键词: cardiovascular disease;    estrogen;    sex hormones;    cardiovascular homeostasis;    non-nuclear signaling;   

DOI  :  10.3389/fphys.2021.738218

来源: DOAJ

【 摘 要 】

Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and studied for decades, their full extent remains unclear. Results of the latest clinical studies provide strong evidence of sex differences in the efficacy of drug treatment for heart failure, thereby possibly providing new mechanistic insights into sex differences in CVDs. In this review, we discuss the significance of sex differences, as rediscovered by recent studies, in the pathogenesis of CVDs. First, we provide an overview of the results of clinical trials to date regarding sex differences and hormone replacement therapy. Then, we discuss the role of sex differences in the maintenance and disruption of cardiovascular tissue homeostasis.

【 授权许可】

Unknown