Molecular Functions of Hydrogen Sulfide in Cancer

Pathophysiology

Islam Z. Mohammad¹  Rodney E. Shackelford¹  Christopher G. Kevil¹  Ghali E. Ghali²  Fawaz Alotaibi²  Andrew T. Meram²  Stavan Patel²  David Kim² 

[1]Department of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, LA 71130, USA

[2]Head & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA

关键词: hydrogen sulfide;    H₂S;    cancer;    cystathionine β-synthase;    cystathionine γ-lyase;    3-mercaptopyruvate sulfurtransferase;   

DOI  :  10.3390/pathophysiology28030028

来源: DOAJ

【 摘 要 】

Hydrogen sulfide (H₂S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H₂S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, H₂S promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia–mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased H₂S-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of H₂S in cancer, with an emphasis on the molecular mechanisms by which H₂S promotes cancer development, progression, dedifferentiation, and metastasis.

【 授权许可】

Unknown