Duration of Contagion of Foot-And-Mouth Disease Virus in Infected Live Pigs and Carcasses

Frontiers in Veterinary Science

Carolina Stenfeldt¹  Ethan J. Hartwig²  George R. Smoliga²  Jonathan Arzt²  Amy H. Delgado³  Miranda R. Bertram⁴ 

[1] Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States;Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY, United States;Monitoring and Modeling, Center for Epidemiology and Animal Health, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, CO, United States;PIADC Research Participation Program, Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States;

关键词: foot-and-mouth disease;    foot-and-mouth disease virus;    FMD;    FMDV;    pig;    transmission;   

DOI  :  10.3389/fvets.2020.00334

来源: DOAJ

【 摘 要 】

Data-driven modeling of incursions of high-consequence, transboundary pathogens of animals is a critical component of veterinary preparedness. However, simplifying assumptions and excessive use of proxy measures to compensate for gaps in available data may compromise modeled outcomes. The current investigation was prospectively designed to address two major gaps in current knowledge of foot-and-mouth disease virus (FMDV) pathogenesis in pigs: the end (duration) of the infectious period and the viability of FMDV in decaying carcasses. By serial exposure of sentinel groups of pigs to the same group of donor pigs infected by FMDV A24 Cruzeiro, it was demonstrated that infected pigs transmitted disease at 10 days post infection (dpi), but not at 15 dpi. Assuming a latent period of 1 day, this would result in a conservative estimate of an infectious duration of 9 days, which is considerably longer than suggested by a previous report from an experiment performed in cattle. Airborne contagion was diminished within two days of removal of infected pigs from isolation rooms. FMDV in muscle was inactivated within 7 days in carcasses stored at 4oC. By contrast, FMDV infectivity in vesicle epithelium harvested from intact carcasses stored under similar conditions remained remarkably high until the study termination at 11 weeks post mortem. The output from this study consists of experimentally determined data on contagion associated with FMDV-infected pigs. This information may be utilized to update parameterization of models used for foot-and-mouth disease outbreak simulations involving areas of substantial pig production.

【 授权许可】

Unknown