Association of Protein and Vitamin D Intake With Biochemical Markers in Premature Osteopenic Infants: A Case-Control Study

Frontiers in Pediatrics

May Kamleh¹  Jalal Abu-Shaweesh²  Sharon Groh-Wargo³  Mohamed Mohamed⁵  Julia Muzzy⁷ 

[1] Department of Epidemiology, Harris County Public Health, Houston, TX, United States;Department of Pediatrics, Cleveland Clinic, Cleveland, OH, United States;Department of Pediatrics, MetroHealth Medical Center, Cleveland, OH, United States;Department of Pediatrics, Sanford Children's Hospital, Fargo, ND, United States;Department of Pediatrics, University of North Dakota Grand Forks, Grand Forks, ND, United States;School of Medicine, Case Western Reserve University, Cleveland, OH, United States;School of Medicine, North Dakota State University, Fargo, ND, United States;

关键词: vitamin D;    neonatal;    osteopenia;    low birth weight (LBW) infant;    nutrition;    neonatal intensive care;   

DOI  :  10.3389/fped.2020.546544

来源: DOAJ

【 摘 要 】

Osteopenia in preterm infants (OP) remains an important challenge and is largely dependent on nutritional post-natal intake of factors influencing bone mineralization. We conducted a prospective case-control study to evaluate the importance of protein and vitamin D intake in OP among neonates with birth weight <1,250 g. Simultaneous serum parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), vitamin D and protein levels were measured during the first six post-natal weeks. At 6 weeks of age, OP was evaluated using wrist radiographs. Comparisons were analyzed using multivariate linear regression, receiver operating characteristic curves, χ2 and Wilcoxon Rank Sum. Of the 26 premature infants enrolled, 13 developed radiographic OP. Daily protein intake (coef = −0.40, p = 0.001) and vitamin D concentrations (21 ± 5.7 ng/ml) were significantly lower in the OP group compared to non-OP subjects. ALP concentration exceeding 619 IU/L, sensitivity of 76.9% and specificity of 75%, was predictive of OP at 6 weeks post-natally. PTH levels were higher at 6 weeks in OP subjects (193 ± 102.5 pg/ml, p < 0.001) compared to non-OP subjects. The findings in this study support the role of vitamin D and protein intake in the development of OP in VLBW infants and inform future practice and research on best practices for OP management.

【 授权许可】

Unknown