Interictal Discharge Pattern in Preschool-Aged Children With Tuberous Sclerosis Complex Before and After Resective Epilepsy Surgery

Frontiers in Neurology

Yangshuo Wang¹  Tinghong Liu¹  Guojun Zhang²  Shuli Liang²  Liu Yuan²  Shuhua Cheng³  Junchen Zhang⁴  Shaohui Zhang⁵ 

[1] Functional Neurosurgery Department, National Children's Health Center of China, Beijing Children's Hospital, Capital Medical University, Beijing, China;Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China;Neurology Department, National Children's Health Center of China, Beijing Children's Hospital, Capital Medical University, Beijing, China;Neurosurgery Department, Affiliated, Jining Medical College, Jining, China;Neurosurgery Department, People's Liberation Army (PLA) General Hospital, Beijing, China;

关键词: epilepsy;    epileptogenic tuber;    interictal discharge (IID);    scalp electroencephalographs (EEGs);    tuberous sclerosis complex (TSC);   

DOI  :  10.3389/fneur.2022.868633

来源: DOAJ

【 摘 要 】

ObjectiveTo analyze the interictal discharge (IID) patterns on pre-operative scalp electroencephalogram (EEG) and compare the changes in IID patterns after removal of epileptogenic tubers in preschool children with tuberous sclerosis complex (TSC)-related epilepsy.MethodsThirty-five preschool children who underwent resective surgery for TSC-related epilepsy were enrolled retrospectively, and their EEG data collected before surgery to 3 years after surgery were analyzed.ResultsTwenty-three (65.7%) patients were seizure-free post-operatively at 1-year follow-up, and 37–40% of post-operative patients rendered non-IID on scalp EEGs, and patients with focal IIDs or generalized IID patterns on pre-operative EEG presented a high percentage of normal post-operative scalp EEGs. IID patterns on pre-operative scalp EEGs did not influence the outcomes of post-operative seizure controls, while patients with non-IID and focal IID on post-operative EEGs were likely to achieve post-operative seizure freedom. Patients with new focal IIDs presented a significantly lower percentage of seizure freedom than those without new focal IIDs on post-operative EEGs at 3-year follow-up.ConclusionOver 1/3 children with TSC presented normal scalp EEGs after resective epileptsy surgery. Patients with post-operative seizure freedom were more likely to have non-IIDs on post-operative EEGs. New focal IIDs were negative factors for seizure freedom at the 3-year follow-up.

【 授权许可】

Unknown