Cancer-Related Alopecia: From Etiologies to Global Management

Cancers

Stanislas Quesada¹  Alexandre Guichard²  Frédéric Fiteni³ 

[1] Institut Régional du Cancer de Montpellier, 34090 Montpellier, France;Legacy Healthcare Switzerland SA, 1066 Epalinges, Switzerland;Medical Oncology Department, University Hospital, 30900 Nîmes, France;

关键词: alopecia;    supportive care;    psycho-oncology;    quality of life;   

DOI  :  10.3390/cancers13215556

来源: DOAJ

【 摘 要 】

Alopecia represents a multifaceted challenge with distinct etiologies and consequences. Transposed to the world of oncology, different types of alopecia and molecular pathways have been characterized, allowing a better understanding of the underlying mechanisms. In patients with cancer, alopecia can be iatrogenic (i.e., due to conventional chemotherapies, endocrine therapies, targeted therapies, immunotherapies, radiotherapy and surgery) or a direct consequence of the disease itself (e.g., malnutrition, scalp metastases and paraneoplastic syndromes). Identification of the actual incriminated mechanism(s) is therefore essential in order to deliver appropriate supportive care, whether preventive or curative. On the preventive side, the last few years have seen the advent of the automated cooling cap, a prophylactic approach supported by several randomized clinical trials. On the curative side, although the treatments currently available are limited, several promising therapeutic approaches are under development. Appropriate alopecia management is essential, particularly regarding its psychological repercussions with significant consequences on the quality of life of patients and their family and with a potential impact on treatment compliance.

【 授权许可】

Unknown